It has been hypothesized that transplanting simultaneous pancreas kidney (SPK) grafts from donors with a history of cardiac arrest and cardiopulmonary resuscitation (CACPR) leads to inferior post-transplant outcomes due to organ hypoperfusion during cardiac arrest and mechanical trauma during resuscitation. Using SRTR data, we identified 13,095 SPK transplants from 2000-2018, of which 810 (6.2%) were from donors with a history of CACPR. After inverse probability of treatment weighting on donor and recipient characteristics, we found that 1-, 5- and 10-year patient (CACPR: 96.4%, 89.9% and 78.9%; non-CACPR: 96.3%, 88.9% and 76.0%; p=0.3), death-censored pancreas graft survival (CACPR: 89.3%, 82.7%, 75.0%; non-CACPR: 89.9%, 82.7%, 76.3%; p=0.7), and death-censored kidney graft survival (CACPR: 97.0%, 89.5%, 78.2%; non-CACPR: 96.9.9%, 88.7%, 80.0%; p=0.4) were comparable between the two groups. There were no differences in the risk of pancreatitis (CACPR: 2.9%, non-CACPR: 2.4%; weighted OR= 0.74 1.22 2.02 ; p=0.4), anastomotic leak (CACPR: 1.6%, non-CACPR: 2.0%; weighted OR= 0.54 1.02 1.93 ; p>0.9), or median length of hospital stay (CACPR: 8 days, non-CACPR: 9 days; p=0.6) for recipients of CACPR vs. non-CACPR donors. Our findings suggest that CACPR donors could be used to expand the SPK donor pool without compromising short or long-term outcomes.

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4951255
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Wednesday, February 5, 2020 - 13:00
FeedBuilder article authors: 
Franka Messner, Joanna W Etra, Yifan Yu, Allan B Massie, Kyle R Jackson, Gerald Brandacher, Stefan Schneeberger, Christian Margreiter, Dorry L Segev
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Department of Visceral, Transplant and Thoracic Surgery, Center of Operative Medicine, Medical University of Innsbruck, Innsbruck, Austria.
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https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=32026618
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FeedBuilder title: 
Outcomes of simultaneous pancreas and kidney transplantation based on donor resuscitation